In this noninterventional prospective study, the effectiveness and safety of an angiotensin-converting enzyme inhibitor (ACEI) and a nondihydropyridine calcium channel blocker (CCB) in a single-tablet combination were investigated in patients with hypertension and comparatively higher heart rates at baseline together with T2DM as a comorbidity condition. The gene discussed is ACE; the disease is type 2 diabetes mellitus.