MGMT and central nervous system cancer: Isocitrate dehydrogenase (IDH) mutations, codeletion of chromosomal arms of 1p and 19q, O6-methylguanine-DNA methyltransferase (MGMT) promoter gene methylation, and histone protein H3.3 or H3.1lys27Met mutations (H3K27M) represent prevalent subtypes in the population with glioma [2].