ESR1 and neoplasm: The ROC curve was used to identify the sensitivity and specificity of the tumor grade (p = 0.015), tumor stage (p = 0.328), T size (p = 0.857), node metastases (p = 0.173), PR (p = 0.669), ER (p = 0.430), HER2 (p = 0.855), and Ki-67 (p = 0.935) (Tables 8 and 9 and Figure 4).