In mice with conditional deletion of the GR in macrophages, stimulation of toll-like receptor 4 by lipopolysaccharide results in increased mortality and pronounced cytokine production of TNF-α, IL-1β, IL-6, and IL-10213,234 suggesting GR signaling in macrophages has anti-inflammatory effects in sepsis and inflammatory diseases. The gene discussed is NR3C1; the disease is Sepsis.