Further analysis of breast tumors showed reduced levels of MKI67 and elevated levels of Bax and cleaved caspase 3 in HNK group in comparison to vehicle-treated group while HNK + CQ group exhibited lowest expression of MKI67 and highest expression of Bax and cleaved caspase 3 (Fig. 7h, i). The gene discussed is CASP3; the disease is breast neoplasm.