As a key enzyme for base excision repair with the function of alleviating pulmonary fibrosis, 8-oxoguanine DNA glycosylase (Ogg1) associated with aconitase-2 (Aco-2) could prevent mtDNA damage, p53 mitochondrial translocation, and intrinsic apoptosis in AECs64. The gene discussed is ACO2; the disease is pulmonary fibrosis.