CASP1 and endometrium neoplasm: Yang et al. recently demonstrated using a mouse model of human endometrial tumor xenograft that HW has an antitumor effect that was sufficient to inhibit xenograft volume and weight of endometrial tumors via the ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway, indicating a biphasic effect of H2 on cancer that involves the promotion of tumor cell death and protection of normal cells [129].