Intertwined with this, the specific proteins including ACON, GRP75, PCCA, ENOA, KCRM, ODPA, and MDHC which are mostly associated with critical metabolic processes in mitochondria are highly oxidatively modified under ADR application, leading to cardiomyopathy, whereas SMAE treatment could remarkably abolish the oxidative stress via promoting the antioxidant capacity and therefore maintaining the normal physiological function of cardiomyocytes. The gene discussed is HSPA9; the disease is cardiomyopathy.