The MCODE score in module 2 was 8.4, including 16 nodes and 63 edge lines (Fig. 3D), and the KEGG pathway enrichment analysis of module 2 mostly identified terms such as ‘protein digestion and absorption’, ‘ECM-receptor interaction’, ‘focal adhesion’, ‘amoebiasis’, ‘PI3K-Akt signaling pathway’ and ‘platelet activation’ (P<0.05; Fig. 3E). This evidence concerns the gene AKT1 and amebiasis.