The expression levels of UBE2C (Fig. 7A), CDKN3 (Fig. 7B), CKS2 (Fig. 7C), KIF20A (Fig. 7D) and RAD51AP1 (Fig. 7E) in EAC and ESCC were significantly higher than those in normal tissues. The gene discussed is CDKN3; the disease is esophageal squamous cell carcinoma.