Seventh, it is worth noting that previous meta-analyses found that IL-10 − 819C/T (rs1800871), IL-10 − 592C/A (rs1800872), IL-10 − 1082A/G (rs1800896), TNF-α − 308 G/A (rs1800629) and ADIPOQ + 45T/G (rs2241766) were significantly associated with the risk of T2DM, whereas IL6 − 174 G/C (rs1800795) was significantly associated with the risk of nephrology in T2DM patients [19–22]. Here, TNF is linked to type 2 diabetes mellitus.