For the treatment of DR, Qiming Granule is commonly used, which can relieve retinal hypoxia and ischemia by increasing the retinal blood flow and improving blood circulation [49], and also lower the HbAlc level [50]; Compound Xueshuantong Capsule can protect DR by regulating the Hippo pathway [51], and reducing the VEGF expression, aldose reductase activity, whole blood viscosity and plasma viscosity [52], and lowering blood sugar levels [53]. Here, AKR1B1 is linked to ischemia.