In vitro experiments showed that circITGA7 could bind to hsa-miR-370-3p to upregulate its target gene NF1 level and then inhibit Ras pathway, further reduce Ras protein level and the phosphorylation level of Erk and Akt, and finally play a role in inhibiting the growth and metastasis of osteosarcoma. This evidence concerns the gene AKT1 and osteosarcoma.