Tumor cells exposed to ICD inducers undergo apoptosis; simultaneously, damage-associated molecular patterns (DAMPs) such as calreticulin (CRT), adenosine triphosphate (ATP), high mobility group box 1 (HMGB1), and heat shock protein (HSP)70 and 90 are exposed or released on the cell surface [7, 8]. Here, HMGB1 is linked to neoplasm.