Other studies have shown that kaempferol inhibits the activation of the Src-Akt1-ERK1/2 signal pathway by targeting VEGF and PGF and thus inhibits the angiogenesis of human retinal endothelial cells [19], which may permit the treatment of neovascularization caused by diabetic retinopathy. This evidence concerns the gene MAPK3 and diabetic retinopathy.