2 Core target genes, ESR1, ERBB2, IGF1R, AR, NOTCH1,and ALB, are mainly involved in the transcription of RNA polymerase II promoters, steroid hormone mediated signaling pathway, protein autophosphorylation, positive regulation of apoptosis process, protein phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, response to lipopolysaccharide, and other biological processes, which inhibits liver cancer. The gene discussed is ESR1; the disease is liver cancer.