In our study, the bone formation-specific genes Wnt10b and Osx were upregulated, whereas the adipogenesis-related genes Fndc5, PPARγ, and Fabp4 were downregulated in the JGSQP group compared with the Model group, indicating that JGSQP promoted bone formation and inhibited bone marrow lipogenesis, thereby controlling the bone-fat balance in mice with OVX-induced osteoporosis and KYD. Here, FNDC5 is linked to osteoporosis.