RUNX2 and osteoporosis: For instance, it has been reported that in osteoporosis, upregulated miR-23b, miR-3077-5p, miR-212, and miR-384 inhibit osteogenesis by directly targeting Runx2 gene [106–108], while in ONFH, upregulated miR-596 and miR-708 hinder osteogenesis by binding to Smad3 transcripts to suppress Runx2 gene expression [109, 110].