In summary, by applying ESTIMATE algorithm, and mining from ArrayExpress dataset and other two independent GEO cohorts, we got 14 prognostic genes (ABCA6, SEPP1, SLAMF8, GPR171, ABCA9, ARHGAP15, IL7R, HLA-DPB1, GZMA, GPR183, CCL19, ITK, FGL2, and CD1C) having the capacity to illustrate the prognosis of neuroblastoma patients. The gene discussed is SLAMF8; the disease is neuroblastoma.