ALK and non-small cell lung carcinoma: For instance, in the series reported by Lin et al. and comprised of eighteen evaluable patients with ALK-rearranged NSCLC and symptomatic (eight patients) or large (≥1 cm; 10 patients) CNS metastases, intracranial ORR with alectinib was 72% and median intracranial duration of response was 17.1 months (95% CI, 14.3: not evaluable); all eight patients with symptoms attributable to CNS metastases had clinical improvement upon starting alectinib therapy [32].