PPARG and fatty liver disease: Finally, the effects of both Pio and diet on liver triglyceride content and hepatic steatosis varied depending on hepatocellular PPARγ expression: Pio increased liver fat content in WT mice on control diet but decreased these measures in the corresponding KO mice, and HFD-exposed KO mice displayed reduced liver triglycerides and less hepatic steatosis than the corresponding WT mice (Figures 1(h) and 2).