HSPA5 and neoplasm: To determine whether the immunity induced by high-dose-IR and Bip inhibition refuses tumor rechallenge and promotes antitumor efficacy of radiochemotherapy, the s.c. allografts of C57BL/6J mice were treated with Bip inhibitor and 10 Gy irradiation, then primary tumors were resected, and mice were rechallenged intracranially with live GL261s (Fig. 7a).