Among the implicated genes (Supplementary Data 6) it is worth highlighting RAD52, an enzyme involved in DNA repair of double-strand breaks, TELO2, a regulator of DNA damage response kinases like ATM70,71, and RPTOR, an essential component of the mTORC1 complex which has been implicated in AML development and progression72. Here, TELO2 is linked to acute myeloid leukemia.