The correlation between VAV2 transcript levels and the c-MYC- (Fig. 6j, bottom right panel) and YAP/TAZ-regulated (Fig. 6k, bottom right panel) gene signatures is lost in most cases when the hnSCC samples are not stratified according to HPV status, further linking this Vav2Onc-driven pathobiological program to HPV– tumor cases. Here, MYC is linked to neoplasm.