VAV2 and neoplasm: Interestingly, ≈37.4% and 40.5% of the up- and downregulated subsets (referred to hereafter as “redundant transcriptome”) display an opposite regulation to that found in the previously described response of the skin of Vav2–/–;Vav3–/– mice to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA)17 (Supplementary Fig. 4, Supplementary Table 2).