All CpGs that were highly significant [−log(P-value) > 50] were negatively correlated with the expression of their corresponding gene, and many of them were recurrent in several tumor types, namely CpGs in TDRD1 (n = 16 tumor types), RNF17 (n = 13 tumor types), SP140L (n = 5 tumor types), and STK31 (n = 3 tumor types) (Fig. 3D). This evidence concerns the gene TDRD1 and neoplasm.