H1-2 and cancer: Six additional ERGs would still be classified as drivers at a score < 1.5 but with manual curation by Bailey et al. (2018), and these are ATR, EZH2, HIST1H1C, PHF6, SMARCB1, and TET2. The ConsensusDriver score matched to a high extent with the driver potential predicted based on SNA frequencies in each cancer type, and to a lesser extent with that predicted based on CNA, FC, or Z-scores (Fig. 4A); the latter three, if matching with ConsensusDriver score, never occurred without SNAs, further emphasizing the importance of SNAs in the derivation of ConsensusDriver score (Fig. 4A).