KMT2D and neoplasm: Among ERGs that could be classified as tumor suppressors, KMT2D, KMT2C, ARID1A, ATRX, CREBBP, and PBRM1 were frequently mutated in many cancer types, whereas oncogenic ERGs were each mutated in specific cancer types, mainly IDH1 in LGG and DNMT3A in LAML (Supplemental Fig. S5A,B).