HM and HA, but not DM, modulators were highly represented among the top 100 Pan-Cancer Driver ERGs, probably because DM modulators are mostly altered by SNAs (Fig. 2G vs. 2H), and hence are characterized by ConsensusDriver (e.g., IDH1 and DNMT3A) (Fig. 4A) rather than Pan-Cancer Driver (Fig. 4D; Supplemental Fig. S5B) profiles. The gene discussed is DNMT3A; the disease is polyarteritis nodosa.