ATRX and breast cancer: KEGG analysis also revealed NOTCH and FOXO signaling pathways, two major pathways involved in breast cancer development, and several of the identified putative epidrivers (i.e., ATRX, PHF11, NAP1L2, and PRDM5) show high mutation rate, copy number depletion, and/or decrease in expression in breast cancer (Supplemental Table S3).