Six additional ERGs would still be classified as drivers at a score < 1.5 but with manual curation by Bailey et al. (2018), and these are ATR, EZH2, HIST1H1C, PHF6, SMARCB1, and TET2. The ConsensusDriver score matched to a high extent with the driver potential predicted based on SNA frequencies in each cancer type, and to a lesser extent with that predicted based on CNA, FC, or Z-scores (Fig. 4A); the latter three, if matching with ConsensusDriver score, never occurred without SNAs, further emphasizing the importance of SNAs in the derivation of ConsensusDriver score (Fig. 4A). The gene discussed is PHF6; the disease is cancer.