PTGER2 and myeloid sarcoma: In another mouse model of MS (induced by cuprizone), COX-2–PGE2-EP2 axis has been proposed to play an important role by aggravating oligodendrocyte apoptosis during the onset of MS: AH6809 (EP1/2 and DP1 antagonist), reduced cuprizone-induced oligodendrocyte apoptosis, demyelination, neuroinflammation, and motor deficits.