In mice, deficiency of the EP2 receptor or treatment with the EP2-receptor antagonist, PF-04418948, reduced azoxymethane and dextran sodium sulfate–induced colon tumorigenesis associated with downregulation of proinflammatory genes (e.g., TNF-α, IL-6, CXCL1, and COX-2) in tumor-associated fibroblasts and neutrophils (Ma et al., 2015). The gene discussed is PTGER2; the disease is neoplasm.