CXCL12 and Carcinoma, Lewis Lung: Specific EP3- or EP4-receptor agonists (ONO-AE-248 and ONO-AE1-329) stimulated CXCL12 expression by mice fibroblasts in vitro, whereas EP3- or EP4-receptor deficiency reduced stromal expression of CXCL12/ C-X-C motif chemokine receptor 4 in mice implanted with Lewis lung carcinoma cells (Katoh et al., 2010).