In addition, they found that mPGES-1 deficiency can attenuate the symptoms of the disease, and there is a positive correlation between mPGES-1 immunoreactivity in microglia/macrophages and the severity of MS disease, indicating that mPGES-1-PGE2 pathway plays a role in the progression of MS (Kihara et al., 2009). This evidence concerns the gene PTGES and myeloid sarcoma.