PTGER SNPs are associated with different pathologies: EP2 in essential hypertension (Sato et al., 2007), EP3 in Stevens-Johnson syndrome/toxic epidermal necrolysis (Ueta et al., 2015; Mieno et al., 2020), and in asthma (Park et al., 2007) as well as EP4 in African Americans with inflammatory bowel disease (Brant et al., 2017), in gastric cancer (Heinrichs et al., 2018), and in multiple sclerosis (Matesanz et al., 2012). This evidence concerns the gene PTGER2 and hypertensive disorder.