Furthermore, missense variants in GDF2 gene (OMIM 605120), which encodes bone morphogenetic protein-9 (BMP9) and is located on chromosome 10q, have been found in 3 individuals with a vascular phenotype overlapping with HHT, characterized by epistaxis and telangiectasia without solid-organ involvement [5]. This evidence concerns the gene GDF2 and telangiectasis.