Unlike the functions of the BRD2/ET domain interacting with KSHV LANA and MLV integrase, NDV undergoes genomic replication, mRNA transcription, protein synthesis, and assembly of virus components in the cytoplasm, but the NDV M-chBRD2/ET interaction in the nucleus mainly assists in viral RNA synthesis and transcription until later in infection. The gene discussed is BRD2; the disease is infection.