More importantly, we found that c-MYC could regulate expression of LPP-AS2, suggesting that LPP-AS2 is transcriptionally regulated by c-MYC, and functions as an oncogene in glioma via an miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop (Fig. 7). The gene discussed is AKT1; the disease is central nervous system cancer.