To this end, three neuroblastoma cell lines—SK-N-BE(2), SH-SY5Y, and IMR-32—were cultured in the presence of increasing concentrations of PON (0.325–10 μM) for 24h to assess the sub-toxic doses (<IC50) of the drug (Supplementary Fig. S1A). Here, PON1 is linked to neuroblastoma.