ALB and early-onset autosomal dominant Alzheimer disease: The BBB permeability response in our model of histone injection appears to be subtle and size-selective, compared to animal models of Alzheimer’s disease and ischemia, where large molecules like albumin-conjugated Evan’s blue (~ 68 kDa) and IgG (~ 150 kDa) can permeate across the BBB [42–44].