In the multivariate analysis, after adjusting for confounding factors such as age, sex, diabetes duration, BMI, glycated hemoglobin, SBP, GFR, smoking, and insulin, the group with highest quartile of baPWV (Q4) still had a significantly higher risk of all-cause mortality (HR 2.55 95% CI 1.49–4.35, P = 0.001), CV-mortality (HR 5.57 95% CI 1.19–26.18, P = 0.030), and cancer-mortality (HR 4.35, 95% CI 1.57–12.03, P = 0.005) with the exception of other-cause mortality (HR 1.59, 95% CI 0.78–3.26, P = 0.207). The gene discussed is INS; the disease is diabetes mellitus.