IGHE and asthma: Further, similar to our observation in pediatric asthmatics, a study noted that bacterial colonization of neonatal airways at 1 month of age was observed to predominate with pathogenic Streptococcus pneumoniae, Haemophilus influenzae or Moraxella catarrhalis, which in turn increased their risk and severity of wheeze as well as increased the total IgE and blood eosinophil counts by the age of 5 years, leading to their diagnosis of clinical asthma by age 5 and also implying their role in the development and progression of asthma [49].