CCNA2 and acute leukemia: Machado-Neto et al. [38] found that the ANKHD1 gene is involved in the Hippo signaling pathway and can promote cell growth and cell cycle progression by upregulating Cyclin A. In an acute leukemia human study, Traina et al. [39] found that the ANKHD1 gene may be related with the abnormal phenotype of leukemia cells as a scaffold protein.