INS and Insulin resistance: Furthermore, the administration of 27 g/day (split dose) flavonoid-enriched chocolate (containing 850 mg flavan-3-ols [90 mg epicatechin] and 100 mg isoflavones) to patients with type 2 diabetes, for one year, reduced peripheral insulin resistance, improved insulin sensitivity, and led to a decrease in total cholesterol to HDL-c ratio, and a dcrease in LDL-c [150].