The downregulation of certain miRNAs (miR-126 and miR-200b) and the upregulation of others (miR-18a, miR-20b, miR31 an mir-155) are now related to augmented VEGF production [278], miR-146 is a miRNA that functions as a negative feedback to NF-kB activation induced by IL-1β in retinal endothelial cells and it is also upregulated after 3 months following the onset of diabetes [278]. The gene discussed is IL1B; the disease is diabetes mellitus.