IL-8 is an important chemoattractant that regulates chronic leukocytic inflammation in the vascular walls and ultimately leads to capillary occlusion and retinal ischemia [193], its levels have been reported in the AH of DR patients with 42.20 ± 33.03 pg/mL (mean ± SD) [115]. This evidence concerns the gene CXCL8 and retinal ischemia.