Moreover, oral cinnamon extract treatment caused a downregulation of tryptase and carboxypeptidase A3 (MC-CPA) expression [196] and reduced expression of mast cell proteases (MC-CPA, MCP-1 and MCP-4) and pro-inflammatory mediators (CXCL8, CCL2, CCL3 and CCL4) during colitis in IL-10 knockout mice [197]. The gene discussed is CPA3; the disease is colitis.