INS and obesity due to melanocortin 4 receptor deficiency: Hyperlipidemia triggers elevation of ROS and proinflammatory cytokines which may be causative factors for lipotoxicity, being predominantly known to be caused by increased rate of lipolysis and repressed synthesis of TG in obesity-affected, insulin-resistant WAT, triggering increased levels of circulating FFA and accumulation of lipids in non-adipose organs (e.g., liver, pancreas, muscles) [81,118].