INS and obesity due to melanocortin 4 receptor deficiency: Moreover, in abdominal AT, an elevated expression of miR-24, miR-30d, and miR-146a was reported in subjects with obesity and T2DM and being positively correlated with secreted frizzled-related protein 4 (SFRP-4), an adipocytokine, which could contribute to T2DM by influencing insulin sensitivity and promoting inflammation [344].