PIK3CA and diabetic cardiomyopathy: Considering diabetic cardiomyopathy, HG-associated myocardial OxS, fibrosis, hypertrophy and apoptosis were also improved via elevation of miR-203 along with reduced signaling via PI3K/AKT pathway due to reduction of expression of phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PI3KCA), a direct target of miR-203 [279].