It is also upregulated in livers of NAFLD and mice models with NASH and hepatic steatosis while targeting SIRT1, PTEN, histone acetyltransferase P300 (P300), FOXO3, cytochrome P450 family 2 subfamily E member (CYP2E1) [359]. This evidence concerns the gene EP300 and metabolic dysfunction-associated steatohepatitis.