To directly assess how downregulation of PI3K/AKT and MAPK/ERK1/2 signaling represses the tumor growth in vivo in TNBC mice, we evaluated the protein levels of cleaved caspase 3 in tumor samples of both groups, which have been previously reported to be regulated by Furin in apoptotic cells [29]. This evidence concerns the gene AKT1 and neoplasm.