In 2016, Sumpter and colleagues, using a CRISPR/Cas9-mediated approach in HeLa cells, FANCC mutant fibroblasts of FA patients, and bone marrow-derived macrophages from Fancc-deficient mice, described the role of FANCC, as well as of other FA genes, in mitophagy [68]. This evidence concerns the gene FANCC and Friedreich ataxia.