BRCA2 and acute myeloid leukemia: Biallelic mutations in BRCA2 and PALB2 predispose FA patients to develop acute myelogenous leukemia (AML) and embryonic tumors, such as medulloblastoma, neuroblastoma, and Wilms tumors, while mutations in other FA genes are associated with an increased incidence of squamous cell carcinoma, mostly affecting the head and neck (HNSCCs) and vulvovaginal regions.