This assumption is supported by several examples where the mutation/downregulation of some mitophagy receptors (proteins that link damaged mitochondria to autophagosome) such as BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) or mitophagy-related enzymes (such as PTEN-induced putative kinase 1 (PINK1) or PARKIN) has been identified in many human cancer types [144]. The gene discussed is PINK1; the disease is cancer.