Very recently, molecular insights have emerged about the role of FANCS (BRCA1) in regulating the mitophagy process; FANCS, indeed, inhibits ataxia-telangiectasia mutated (ATM)-AMP-activated protein kinase (AMPK)-DRP1-mediated mitochondrial fission and promotes tumor proliferation and invasion [145]. Here, BRCA1 is linked to neoplasm.