Chemotherapy promotes the release of SP, favoring nausea/vomiting—an effect that is inhibited by NK-1R antagonists (e.g., aprepitant), which exert antiemetic action, and it is also known that radiotherapy increases the level of SP and that treatment with endostatin (an angiogenesis inhibitor) decreases the level of SP; additionally, the inhibitor blocks the growth of tumor cells, and this is probably due to the reduced level of SP [120]. This evidence concerns the gene TACR1 and neoplasm.