EIF4EBP1 and neoplasm: In tumor cells, aprepitant decreases p70 S6 kinase phosphorylation and attenuates the activation of the mTOR signaling axis (Table 2) [89], whereas SP activates mTOR and increases tumor cell growth and metastasis by activating p70 S6 kinase and the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) [90].