RB1 and acute lymphoblastic leukemia: This has been observed in in vitro experiments in many human cancer cell lines (T-ALL BE-13 and B-ALL SD-1 (acute lymphoblastic leukemia); MT-3, MCF-7, MDA-MB-468 and BT-474 (breast cancer); SW-403 (colon carcinoma); 23132/87 (gastric carcinoma); GAMG (glioblastoma); HepT1, H4H6 and HepG2 (hepatoblastoma); HEp-2 (laryngeal carcinoma); H-69 and COR-L2 (lung cancer); MEL HO, COLO 858 and COLO 679 (melanoma); SKN-BE, IMR-32 and KELLY (neuroblastoma); MG-63 (osteosarcoma); PA-TU-8902 and CAPAN-1 (pancreatic carcinoma); Y-79, WERI-Rb-1 (retinoblastoma)) [2,3].