NFE2L3 and cancer: Importantly, The Cancer Genome Atlas (TCGA) indicates that the NRF3 gene is remarkably upregulated in many cancer tissues, such as colorectal adenocarcinoma (COAD), rectal adenocarcinoma (READ), and pancreatic ductal adenocarcinoma (PDAC; it is annotated as PAAD within TCGA) (Figure 1).