IL1B and Cognitive impairment: A large multicentered cohort study conducted in Singapore found that among proinflammatory plasma cytokines—including IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating factor, interferon-γ, and TNF-α—elevated IL-1β and IL-6 were associated with greater self-reported cognitive impairments (p = 0.018 and 0.001, respectively) [25].