In human A375 and mouse B16F10 melanoma cells, bioactive compounds such as gambogic acid [62], melittin [63], kaempferol [64], euplotin C [65], lycorine [66], oxyfadichalcone C [67], isoliquiritigenin [68], muniziqi granule/harmine [69], apigenin [70] and casticin [71] inhibited cell proliferation, colony formation, migration and invasion by downregulating the expression of pPI3K, pAKT, pmTOR and pGSK3β together with the expression of related biomarkers including p27, cyclin D1, LC3, 4EBP1, Bax, Bcl-2 and MMPs. The gene discussed is BCL2; the disease is melanoma.