Binding to (E)-cadherins on colorectal adenoma and cancer cells, FadA, which is only detectable on oral Fusobacterium species, activates the transcriptions of those oncogenes regulated by b-catenin, which is the product of the leader gene CTNNB1, and of some genes involved into the immune-inflammatory response, including IL6, which is presently ranked as a leader gene, and NFKB, belonging to cluster C genes [46]. The gene discussed is IL6; the disease is cancer.