MAPT and Alzheimer disease: By using iPSC-derived neurons induced by NGN2 overexpression from sAD patients, Birnbaum et al. described that neurons from sAD patients showed increased production of reactive oxygen species (ROS) and displayed higher levels of DNA damage, which did not correlate with Aβ or Tau phosphorylation, suggesting that increased ROS production may precede amyloid and Tau pathology in AD [46].