Notably, they described that the TFEB gene, which was upregulated in diseased astrocytes, acted upstream of ten AD genome-wide association studies (GWAS) loci (BIN1, CLDN11, POLN, STK32B, EDIL3, AKAP12, HECW1, WDR5, LEMD2, and DLC1), which are also dysregulated in AD astrocytes. This evidence concerns the gene TFEB and Alzheimer disease.