APP and Alzheimer disease: They reported that mutant cells presented a reduced phagocytic capacity of E. coli fragments as well as of Aβ plaques using co-cultures of derived microglial-like cells with brain slices from APP/PSEN1 mice, providing data sustaining that the presence of AD-related TREM2 mutations made microglia less able to phagocytose Aβ plaques [176].