POLN and Alzheimer disease: Notably, they described that the TFEB gene, which was upregulated in diseased astrocytes, acted upstream of ten AD genome-wide association studies (GWAS) loci (BIN1, CLDN11, POLN, STK32B, EDIL3, AKAP12, HECW1, WDR5, LEMD2, and DLC1), which are also dysregulated in AD astrocytes.