Notably, we have recently demonstrated that tumor-derived PGE2 drives the nuclear accumulation of p50 NF-κB in CD11b+Ly6G-Ly6Chigh M-MDSC, diverting their response to IFNγ towards NO-mediated immunosuppression and reducing TNFα expression [77]. The gene discussed is NFKB1; the disease is neoplasm.