Similarly, exposure of YAMC to E. faecalis-infected macrophages enhances Wnt/β-catenin activation and expression of cancer stem cell markers (e.g., CD44, DCLK1), indicating that the interplay between E. faecalis and macrophages is directly involved in dedifferentiation, reprogramming, and malignant transformation of primary colon epithelial cells [114]. This evidence concerns the gene CD44 and cancer.