DGKA and neoplasm: The anergic T cells and tumor-infiltrating T cells are reported to exhibit similar properties, such as enhanced DGKα levels, attenuated ERK responses (both low basal phosphorylation of ERK and low stimulation-induced phosphorylation of ERK and c-JNK), and downregulated expression of AKT and AKT client proteins (two regulatory factors of NF-κB: IκB and GSK3) [122].