IL1B and osteoarthritis: Ying et al. [2] reported that piperine inhibited the IL-1β-mediated activation of NF-κB and as consequence, the production of PGE2 and NO is downregulated as well as the IL-1β-stimulated gene expression and production of MMP-3, MMP-13, iNOS and COX-2 in human osteoarthritis chondrocyte.