In contrast, the knockdown of Sirt1 with Sirt1-ASO resulted in the elimination of the blocking effect of resveratrol on the expression of mentioned CSC biomarkers, indicating the excellent targeting of resveratrol on CSCs (Figure 6) and the important role of Sirt1 in resveratrol-enhancing anti-tumorigenic effects in CRC cells in multicellular-TME. This evidence concerns the gene SIRT1 and colorectal carcinoma.