We found that transcription factor NF-κB is one of the most important activated down-stream signaling pathways for the TNF-β and the pro-inflammatory multicellular-TME and resveratrol/Sirt1 signaling has a specific modulatory effect against TNF-β-or multicellular-TME-induced phosphorylation of NF-κB and NF-κB-promoted gene end-products in CRC cells. The gene discussed is NFKB1; the disease is colorectal carcinoma.