NFKB1 and neoplasm: Treatment with resveratrol alone resulted in a significant down-regulation of p65-NF-κB expression in CRC cells and nuclear localization in pro-inflammatory multicellular-TME cultures resulting in 25% positive labelled cells, indicating the important synergistic effects of paracrine cross-talk between HCT116, fibroblast cells and T-lymphocytes/TNF-β in supporting tumor promotion.