SIRT1 and colorectal carcinoma: In addition, transfection with Sirt1-ASO but not with the control Sirt1-SO blocked the resveratrol-promoted inhibition of p65-NF-κB in CRC cells and nuclear localization in CRC cell lines, underlining that Sirt1 is one of the major target proteins of resveratrol in resveratrol anti-tumorigenic effects in CRC cells (Figure 4).