It has been described that activation of the pro-inflammatory transcription factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B-cells) in tumor cells stimulates and promotes the cancer-mediated inflammatory response and paracrine signaling of pro-inflammatory cytokines and growth factors in TME, which in turn stimulates tumor progression and malignancy [13]. This evidence concerns the gene NFKB1 and neoplasm.