LTA and colorectal carcinoma: The current study supports this idea that the induction of proliferation, colony formation and invasion of CRC cells in multicellular-TME strongly suggests that high expression of pro-inflammatory T-lymphocyte factors (cytokines, such as TNF-β) and high expression of growth factors from fibroblasts, such as TGF-β3, induce tumorigenesis and thus metastasis of CRC cells.