SIRT1 and neoplasm: In addition, these results suggest that the other anti-tumorigenic effects of resveratrol are partly mediated by the down-regulation of the CSC signaling pathway and these data suggest further that the paracrine cross-talk between CRC tumor cells and stromal cells is important in inducing CSCs and treatment with resveratrol and Sirt1-SO down-regulated the expression of specific CSC biomarkers.