SIRT1 and colorectal carcinoma: Taken together, these results suggest that knock-down of Sirt1 protein with specific ASO down-regulates the formation of Sirt1-NF-κB complexes during tumorigenesis in alginate cultures (Figure 5), and thereby blocks the ability of resveratrol to inhibit NF-κB, which may at least partially inhibit resveratrol-promoting anti-tumorigenic effects in CRC cells.