CASP3 and colorectal carcinoma: Transfection with specific Sirt1-ASO, but not with control Sirt1-SO, inhibited the resveratrol-induced cleavage of caspase-3 in CRC cells in multicellular pro-inflammatory TME cultures (Figure 5), indicating that Sirt1 suppression to mRNA levels is not reversible by resveratrol and Sirt1 is one of the major targeting proteins by resveratrol during resveratrol-induction-apoptosis effects in CRC cells.