SIRT1 and cancer: In the case of CRC, which is associated with chronic inflammation, an anti-inflammatory response might be more beneficial, at least in the early stages of the disease, which may explain why resveratrol is seen to be an effective treatment for CRC cancer in vitro and in vivo [36,79], and thus, partly due to the ability of the resveratrol/Sirt1 axis to change from a pro-inflammatory T-lymphocyte response to an anti-inflammatory effect in the multicellular-TME.