SIRT1 and colorectal carcinoma: Taken together, these findings suggest that the down-regulation of Sirt1 with specific ASO downregulated Sirt1 protein levels and Sirt1-NF-κB complex formation during tumorigenesis in alginate cultures (Figure 5), thereby blocking the ability of resveratrol to phosphorylate NF-κB, which may at least partially inhibit resveratrol-promoting antitumorigenic effects in CRC cells.