CRACD and Azoospermia: As Cracd can act as a β-catenin suppressor in cancer and Cracd global knockout induces intestinal epithelial cell integrity loss and WNT signaling deregulation [10], and the important and key role played by WNT/β-catenin signaling in spermatogenesis [11,12,13,14,15] and azoospermia [16], we carried out detailed spatiotemporal expression profiling of Cracd in both the normal postnatal mouse testis and within two azoospermia mouse models.